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Simufilam dihydrochloride

CAS No. 2480226-06-8

Simufilam dihydrochloride( PTI-125 dihydrochloride )

Catalog No. M24133 CAS No. 2480226-06-8

Simufilam dihydrochloride is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 219 In Stock
25MG 464 In Stock
50MG 602 In Stock
100MG 784 In Stock
200MG 1035 In Stock
500MG 1512 In Stock
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Biological Information

  • Product Name
    Simufilam dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Simufilam dihydrochloride is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease.
  • Description
    Simufilam dihydrochloride is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease. Simufilam dihydrochloride preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PTI-125 dihydrochloride
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    filamin A (FLNA)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2480226-06-8
  • Formula Weight
    332.3
  • Molecular Formula
    C15H23Cl2N3O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    [H]Cl.O=C1N(CC2=CC=CC=C2)C3(CCN(C)CC3)NC1.[H]Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Wang HY, et al. PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer's disease pathogenesis. Neurobiol Aging. 2017;55:99-114.
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