Cart
sales@molnova.com
Simufilam dihydrochloride
CAS No. 2480226-06-8
Simufilam dihydrochloride ( PTI-125 dihydrochloride )
Catalog No. M24133 CAS No. 2480226-06-8
Simufilam dihydrochloride is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 138 | In Stock |
|
| 10MG | 219 | In Stock |
|
| 25MG | 464 | In Stock |
|
| 50MG | 602 | In Stock |
|
| 100MG | 784 | In Stock |
|
| 200MG | 1035 | In Stock |
|
| 500MG | 1512 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameSimufilam dihydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionSimufilam dihydrochloride is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease.
-
DescriptionSimufilam dihydrochloride is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease. Simufilam dihydrochloride preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies.
-
SynonymsPTI-125 dihydrochloride
-
PathwayOthers
-
TargetOther Targets
-
Recptorfilamin A (FLNA)
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2480226-06-8
-
Formula Weight332.3
-
Molecular FormulaC15H23Cl2N3O
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES[H]Cl.O=C1N(CC2=CC=CC=C2)C3(CCN(C)CC3)NC1.[H]Cl
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Wang HY, et al. PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer's disease pathogenesis. Neurobiol Aging. 2017;55:99-114.
molnova catalog
related products
-
Thianthrene
Thianthrene is a sulfur-containing heterocyclic chemical compound that is a derivative of the parent heterocycle called dithiin and is easy to oxidize.
-
Astragaloside A
Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases.
-
GDP366
GDP366, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells. a dual inhibitor of survivin and Op18.
