Simufilam dihydrochloride( PTI-125 dihydrochloride )

Catalog No. M24133 CAS No. 2480226-06-8

Simufilam dihydrochloride is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
5MG	138	In Stock
10MG	219	In Stock
25MG	464	In Stock
50MG	602	In Stock
100MG	784	In Stock
200MG	1035	In Stock
500MG	1512	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

Simufilam dihydrochloride
Note

Research use only, not for human use.
Brief Description

Simufilam dihydrochloride is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease.
Description

Simufilam dihydrochloride is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease. Simufilam dihydrochloride preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies.
In Vitro

——
In Vivo

——
Synonyms

PTI-125 dihydrochloride
Pathway

Others
Target

Other Targets
Recptor

filamin A (FLNA)
Research Area

——
Indication

——

Chemical Information

CAS Number

2480226-06-8
Formula Weight

332.3
Molecular Formula

C15H23Cl2N3O
Purity

>98% (HPLC)
Solubility

——
SMILES

[H]Cl.O=C1N(CC2=CC=CC=C2)C3(CCN(C)CC3)NC1.[H]Cl
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Wang HY, et al. PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer's disease pathogenesis. Neurobiol Aging. 2017;55:99-114.

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